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49ers 48-27 Colts (Dec 22, 2025) Game Recap – ESPN

December 23, 2025
in Market & News
Reading Time: 1 min read
A A
49ers 48-27 Colts (Dec 22, 2025) Game Recap – ESPN
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  1. 49ers 48-27 Colts (Dec 22, 2025) Game Recap  ESPN
  2. QB Brock Purdy and RB Christian McCaffrey help lead 49ers past Colts  ESPN
  3. 49ers vs. Colts: Brock Purdy lights up Indy for 5 TDs, spoils Philip Rivers’ season debut at home in 48-27 win  Yahoo Sports
  4. Niners-Colts on ‘Monday Night Football’: What We Learned from San Francisco’s 48-27 win  NFL.com
  5. See our favorite Colts photos from Week 16 vs 49ers  IndyStar

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